Posted by Larry Hoover on February 12, 2006, at 12:38:39
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » gibber, posted by LizinManhattan on February 9, 2006, at 22:05:56
> Thanks so much for the links. I have bookmarked them and will look at them tomorrow.
There is a link with reference 21 that takes you to an article with this quotation. I think it makes clear how different the patch is from oral intake....
"In bypassing first-pass metabolism, a 24-hour application of transdermally administered selegiline (7.8 mg/24 hr) yields fifty times greater systemic exposure than is provided by single oral doses."