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Side effects of clozapine (Clozaril) Jeroen

Posted by ed_uk on February 11, 2006, at 8:58:54

In reply to Re: TOED UK Clozapine for attempt reverse TD by geodo, posted by Jeroen on February 10, 2006, at 18:14:11

Hi Jeroen

>i dont call TD improvement in my or anyones health like any other disease

I was talking about the recent improvement in your depression and anxiety.

>i will get fazaclo or clozapine witouth blood monitoring, sounds very dangerous aint it?

Yes, it is. I don't think you will be able to obtain clozapine on the internet. Anything you buy which 'claims' to be clozapine is probably a fake. Clozapine is very tightly controlled compared with most drugs. Most pharmacies cannot dispense clozapine, only licensed pharmacies are permitted to supply it.

The dose of clozapine may need to be decreased when it is taken in combination with Seroxat.

>what other risks are there?

Potential side effects of clozapine....

1. Agranulocytosis - the most well known risk of clozapine. Fever may be a symptom, but clozapine can also induce a fever in the absense of agranulocytosis.

2. Seizures - common at high doses

3. Dizziness and fainting, low blood pressure

4. Certain types of heart disease - rare

5. Weight gain, obesity - common

6. Drowsiness, sedation - can be severe

7. Rapid/increased heart rate - common

8. Nausea/vomiting

9. Constipation - common. Bowel obstruction occurs occasionally.

10. Increased dreaming, unusual dreams, nightmares

11. Headache

12. Tremor

13. Excessive salivation, drooling during sleep 'wet pillow'. This is a very common side effect. Dry mouth may also more rarely.

14. Urinary incontinence

15. Sweating

16. Visual disturbances

17. Restlessness, agitation, confusion

18. Disturbance of sexual function, specifically ejaculation

19. Disturbance of liver function, hepatitis

20. Rash

21. Nasal congestion

22. Neuroleptic malignant syndrome - rare

23. Hyperglycemia and Diabetes Mellitus

24. Increased risk of DVT (deep vein thrombosis) and pulmonary embolism.






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