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Re: Selegiline/Deprenyl effective anti-depressant? willyee

Posted by Larry Hoover on February 10, 2006, at 10:00:47

In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by willyee on February 8, 2006, at 11:58:52

> Sorry i forgot to ask something i very much wanted to,would you say the delivery of a drug directly via bloodstream would avoid the problem of poop out.
> My understanding from reading is poop out is when ur body having had just about enough of a foreign substance begins to fight back by building specific anti-enzmyes to keep this substance out and away,hence the longer of introduction of a drug,the more chance your body will start getting wise to it and fighting it.

It is possible that the induction of enzymes is at the heart of poop-out, but I wouldn't put that theory at the top of my "probable causes" list. Enzyme induction tends to be rather rapid, if it's going to occur at all. It's part of our defense against toxic substances, and a tardy response to toxicity could well end in death (hypothetical evolutionary perspective). I'm most inclined towards a tolerance-based mechanism for poop-out.

> Would the patch benifit here.

The patch works well in two situations. The first is maintaining stable blood concentration. Oral dosing is characterized by substantial changes in blood concentration, rising rapidly after a dose, and tapering off to a much lower level just prior to the next dose. The second situation is to provide an alternate route of entry into the body, where normal digestive processes would tend to destroy the drug before it could do any good.

> P.S As a note i have seen your postings since i began posting period on the internet approx 5 years ago,guess im giving respect due i dunno,but glad certain people are around,lol you part of the kind that makes me look smart as i read your info and turn around and pass it along,shhhhh thats a secret.

Thanks, willyee.





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