Posted by yxibow on February 8, 2006, at 13:33:38
In reply to continuing that klonopin discussion..interesting, posted by becksA on February 8, 2006, at 12:05:05
> I found what phillippa said very interesting in that for seizure disorders, up to 20mg (daily?) I'm assuming it is, is taken. That makes me a bit less concerned about my dosing.
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> Another very interesting point is how radically different it can affect different people! some can get by with .25mg daily, which would be a sugar pill for me. I'm now on 6mg daily throughout the day (2mg 3x daily), and am probably going to ask my doc if I can raise it.
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> HOw much does the size of the person affect it? I am 210 pounds, 6'7". I also have had a long history of being extremely overtolerant to drugs, and able to stop cold turkey some of the most difficult drugs in which this is usually the case. (effexor, xanax....etc.)
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> I just find the benzo topic interesting (of course it does heavily apply to me so....yeah :) )
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> thanks
I am also a big boy, in weight that is, a little bit more than you but 5'11. Its hard to say -- most drugs are based on blood level, and the size of the body can have little effect on this as we all generally have proportioned brains, blood vessels, etc. Its always been something I've wondered -- I do tend to metabolize medication faster and generally have higher doses than others, but that could be as much to do with my genetic makeup as anything else. Some people are deficient in a certain liver CYP that keeps a higher blood level in the body because it takes longer to break down things (if I'm recalling correctly, I dont have the information in front of me.)Alcohol is one of those drugs that is almost definately dependent on weight and gender, no matter how many brewskis someone can claim they can down and go drive a mack truck, they're actually intoxicated. They may have just cleverly over time gotten used to it.
So, who knows ?
Tidings
Jay
poster:yxibow
thread:607509
URL: http://www.dr-bob.org/babble/20060205/msgs/607539.html