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Re: Revolutionary approach to depression

Posted by linkadge on December 31, 2005, at 19:14:39

In reply to Re: Revolutionary approach to depression » linkadge, posted by Pfinstegg on December 31, 2005, at 17:50:59

I remember that study, it was entitled something like "mice raised on prozac grow up depressed" or something.


It is my understanding that serotonin can be both anxiolytic and anxiogenic. The amygdala is loaded with 5-ht2a receptors, for instance.

Medicinal herbs usually have all sorts of interesting receptor binding. For instance marajuanna, acts to agonize 5-ht1a, but antagonize 5-ht2a, and 5-ht3.

I have a feeling that SSRI's can make things worse for some people due to the fact that the drugs increase serotonin in the amygdala.

Certain other antidepressant compound show more selectivity. For instance rTMS and ECT increase hippocampal serotonin, but don't really affect serotonin in too many other regions.

This following study was interesting, it demonstrated rTMS induced changes in high anxiety mice only.

http://www.wireheading.com/rtms/rats.html

I wonder how my doctor would react to a Tianeptine request?


Linkadge


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URL: http://www.dr-bob.org/babble/20051231/msgs/593814.html