Posted by linkadge on December 28, 2005, at 18:33:24
In reply to Re: What to do if Nardil and Parnate were discontinued » linkadge, posted by Tomatheus on December 28, 2005, at 14:38:54
The really dumb thing, is that if the drug companies want to target as many people as possable, they might almost want to try the MAO inhibitor route.
SSRI's don't routeenly or consistantly make the average person better than well. MAO's on the other hand, were discovered based on their propenisty to make normal people feel better than well.
MAO's could also be targeted towards the cigarette smokers. Parnate could probably get more people off the cigarettes than could say wellbutrin, since smoking is not purely dopaminergic. Tobacco inhibits both MAO A, and B.
I know that the drug companies have marketed the SSRI's for everything upto and including a bad hair day, mainly because they can. I don't think they have that option with MAOIs. Also a lot of people's depression is not so bad that they would have to give up on sausage.
If MAOI's were not as "dangerous", the drug companies could probably do the same with the MAOI's that they did with the SSRI's.
I would argue that the only reason the SSRI's are so widely distributed is reated to their presumed safety. I think that even the notion that MAOI's "only help a small subset of depressed people", is just a drug company attempt to direct us towards the newer SSRI drugs. How do we know that they only help a small subset of the depressed population? They've only been given to a small subset of depressed people. Maybe if they were used first line, remission rates would be higher.
For all the placebo's I have ingested over the years, parnate was really the only "active drug".
I won't likely get another shot at an MAOI. No doctor wants to take the "risk"