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Moclobemide vs P-babble » Tomatheus

Posted by ed_uk on December 28, 2005, at 15:23:07

In reply to Re: What to do if Nardil and Parnate were discontinued » linkadge, posted by Tomatheus on December 28, 2005, at 14:38:54

Hi T

Thanks for the interesting post :)

>there is little doubt in my mind that there are some individuals (note: I'm not saying *all* individuals) who would benefit from a potent selective inhibitor of MAO-A

I agree, very much so.

I've often wondered whether p-babble has created an unrealistically negative impression of moclobemide. Most babblers who've taken moclobemide have been very treatment resistant (they have generally imported it into the US following multiple unsuccesful trials of other ADs). Moclobemide has, after all, proved to be an effective antidepressant in numerous clinical trials.

Moclobemide's official maximum dose is 600mg/day (300mg bid). Nevertheless, some sources have suggested that doses up to 1200mg/day might be necessary. Given moclobemide's reversibility and short duration of action, some patients might benefit from taking it in multiple divided doses eg. 150-300mg four times a day. Having said that, I'm sure other people can benefit from much less!

Ed


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URL: http://www.dr-bob.org/babble/20051221/msgs/592794.html