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Re: Effexor metabolite submitted for FDA approval

Posted by jrbecker on December 23, 2005, at 15:18:17

In reply to Re: Effexor metabolite submitted for FDA approval » jrbecker, posted by ed_uk on December 23, 2005, at 15:02:08

desvenlafaxine is an Effexor metabolite that only differs by the removal of a methyl group. Wyeth is contending that it is more of a balanced 5-HT/NE compound than its parent, however, I'm not sure the balanced ratio will reach the level of its main SNRI contender, Cymbalta (duloxetine).

Scepticism is certainly warranted given the debate over lexapro/celexa, however, one blog makes the comparison between imipramine and desipramine in showing how a minor tweak of a compound actually did lead to a significantly superior tricyclic.

http://trots.blogspot.com/2005_05_01_trots_archive.html

Nonetheless, I don't think anybody's looking for it to be a major breakthrough.


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poster:jrbecker thread:591573
URL: http://www.dr-bob.org/babble/20051221/msgs/591603.html