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Re: Desoxyn metabolism/pharmacology

Posted by mike99 on December 3, 2005, at 13:14:27

In reply to Re: Desoxyn metabolism/pharmacology, posted by jamestheyonger on December 1, 2005, at 23:09:41

Thanks for all the info. Hopefully a cardiac med will help out.

Do stimulants cause the coronary arteries to constrict? I realize they constrict the peripheral vasculature resulting in increased blood pressure, but sometimes I get a chest tighness/pain on even 1.25 mg of Dex, even though at this dose neither my heart rate or blood pressure are hardly elevated.

Anything above 10 mg of Ritalin causes me marked chest pain.

Chest pain as I understand comes from an imbalance between cardiac blood/oxygen supply and demand. I can run several miles followed by heavy weight lifting with no chest pain whatsoever and nothing but normal increases in heart rate/ blood pressure. However, even 1.25-2.5 mg of Dex causes brief but noticeable chest pain without any significant increase in cardiac oxygen demand.

I've heard that stimulant induced cardiomyopathy (usually seen with abuse) may be related to constriction of and injury to the smallest arteries supplying the heart (arterioles). I've had my coronary arteries checked on an MRI with a contrast dye to see the them and they're normal. Also had a normal stress echocardiogram.

Any thoughts on why stimulants would cause chest pain in someone without coronary/heart disease/normal thyroid and in doses that do not noticeably affect cardiac oxygen demand? I'm really puzzled by this.




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