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Re: testosterone w/ADs

Posted by jamestheyonger on December 1, 2005, at 14:18:45

In reply to Re: testosterone w/ADs, posted by Declan on December 1, 2005, at 12:24:19

"My lipid profiles are really good, but I dunno if that's the T. I'd imagined it was diet, but now you mention it, increasing cholesterol may be the body's way of trying to correct low hormone levels."

There is a correlation between being overweight and higher estrogen in males. In males production of estrogen is how the body controls production of T. Fat is converted to estrogen. As estrogen goes up T goes down. A negative feedback loop. I would think increased cholesterol (note that is *sterol, the precursor to steroids) would increase estrogen either directly or via the fact
that those who are overweight tend to have worse lipid profiles.

This is starting to look like an icky downward spiral. AD are associated with weight gain, weight gain is associated with increased estrogen
and lowered T, AD's or depression lowers T, lower T means more fat is created. Type-II diabetes/ metabolic syndrome follow.

They revised what is called obese, I am ~20 lbs overweight and now considered obese. I get tested for Type-II diabetes this weekend; the icky glucose tolerance test.


http://www.lef.org/protocols/prtcl-130b.shtml#obe :
"A consistent finding in the scientific literature is that obese men have low testosterone and very high estrogen levels. Central or visceral obesity ("pot belly") is recognized as a risk factor for cardiovascular disease and Type-II diabetes. Research has shed light on subtle hormone imbalances of borderline character in obese men that often fall within the normal laboratory reference range. Boosting tes-tosterone levels seems to decrease the abdominal fat mass, reverse glucose intolerance, and reduce lipoprotein abnormalities in the serum. Further analysis has also disclosed a regulatory role for testosterone in counteracting visceral fat accumulation. Epidemiological data demonstrate that relatively low tes-tosterone levels are a risk factor for development of visceral obesity (7, 237).

One study showed that serum estrone and estradiol were elevated twofold in one group of morbidly obese men. Fat cells synthesize the aromatase enzyme, causing male hormones to convert to estrogens (278). Fat tissues, especially in the abdomen, have been shown to literally "aromatize" testosterone and its precursor hormones into potent estrogens (80, 237-242).

Eating high-fat foods may reduce free testosterone levels according to one study that measured serum levels of sex steroid hormones after ingestion of different types of food. High-protein and high-carbohydrate meals had no effect on serum hormone levels, but a fat-containing meal reduced free testosterone levels for 4 hours (243).

Obese men have testosterone deficiency caused by the production of excess aromatase enzyme in fat cells and also from the fat they consume in their diet. The resulting hormone imbalance (too much estrogen and not enough free testosterone) in obese men partially explains why so many are impotent and have a wide range of premature degenerative diseases"


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URL: http://www.dr-bob.org/babble/20051126/msgs/584238.html