Posted by Mistermindmasta on November 29, 2005, at 2:06:17
In reply to Re: Depression caused by immune system? » Mistermindmasta, posted by lunesta on November 28, 2005, at 1:24:48
I find all this to be interesting and whatnot, and probably a bit of new info to me, but I will strongly disagree that psychological stress is the issue. Some people simply self destruct, physically and mentally, under stress. My health deteriorated when I was exposed to stress, but I don't think my lack of ability to handle stress was psychological, it's physiological. Some people, on the other hand, will only temporarily be phased and then feel good upon being exposed to stress. I don't believe these people just know how to handle their emotions better, I actually don't think they really have to try... they just aren't phased by stress. That's just my opinion, which is subject to further falsification.
> Everything can be traced back to the endorphin system, pro-opiomelanocortin mRNA expression and the related opidergic systems in the body.
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> Venlaxaxine, Mitarzipine (eexor, Remeron and Cymbalta) all work via opiodergic systems which is interesting since these are effective for neruopathic pain type syndroms.
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> SSRI's have direct anti bacterial activity, check pubmed. Its relate to tryptophan depletion or something.
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> All autoimmune diseases can be halted using low dose naltrexone which increases endorphins and the related peptides. lowdosenaltrexone.org
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> In the end, I think stress is the problem though. Opioidergic systems are the primary stress system, gaba is backup.
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> I think chronic stress of any type, biological, trauma, emotional can cause increased MU opiod receptor binding of endorphins, and lead to an actual downregulation of your own endorphin system, leading to lowered MU/endorphin/stress/pain tolerance, and MU receptors directly cross talk with the Delta opiod receptors which control the immune system.
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> I agree, with you but it becomes very complex but there is a common factor in nearly every disease state which is loss of stress tolerance, opiodergic dysunctions, and subsequent inflammation/low immune system function.
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poster:Mistermindmasta
thread:582826
URL: http://www.dr-bob.org/babble/20051126/msgs/583233.html