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Re: MAOIs linkadge

Posted by Bob on November 24, 2005, at 0:01:07

In reply to Re: MAOIs, posted by linkadge on November 23, 2005, at 15:53:19

> The idea that antidepressants work via alteration in sleep stages is not a proposition of my own.
> Doctors knew that depression could be treated by either total sleep deprivation or REM sleep interuption. SSRIs reduce REM sleep, as do the MAOI's. Antidepressant withdrawl can cause a REM rebound and subsequenct cholinergic rebound and depression.
> I found it interesting that the MAOI's reduced REM much more than did the SSRI's. The MAOI's are often more clinically effective drugs.
> Reducing rem sleep is often sufficiant to produce antidepressant responce.
> I first was under the impression that antidepressants normalized rem sleep, but some literature seems to suggest that AD's can suppress it much lower than baseline.
> Linakadge

I definitely have trouble with SSRI withdrawl. If MAOIs reduce REM sleep to a much greater degree than SSRIs, would it follow that withdrawal with the former is more troublesome than with SSRIs?




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