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Re: Pyroluria

Posted by Jedi on November 23, 2005, at 3:33:34

In reply to Re: Pyroluria Ed O`Flaherty, posted by Nickengland on November 19, 2005, at 17:15:45

MAOI users: It is possible that phenelzine(Nardil) and other hydrazine MAOIs can cause a deficiency of B6 in some people. The research is mixed on the subject.

J Psychiatry Neurosci. 1994 Nov;19(5):332-4.
Phenelzine reduces plasma vitamin B6.
Malcolm DE, Yu PH, Bowen RC, O'Donovan C, Hawkes J, Hussein M.
Department of Psychiatry, Royal University Hospital, Saskatoon, Saskatchewan.

Plasma levels of the active form of vitamin B6 (pyridoxal phosphate) in 19 patients taking phenelzine were found to be reduced on the average to approximately 54% of the value in a control group. There was no correlation of pyridoxal phosphate level with phenelzine daily dosage over the range of 30 mg to 90 mg. No symptoms of vitamin B6 deficiency peripheral neuropathy were found.

J Clin Psychopharmacol. 1989 Dec;9(6):428-31.
Phenelzine treatment of panic disorder: lack of effect on pyridoxal phosphate levels.
Lydiard RB, Laraia MT, Howell EF, Fossey MD, Reynolds RD, Ballenger JC.
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston 29425.

Earlier reports indicated that phenelzine treatment may result in clinically significant reductions of vitamin B6 in some individuals. Sixteen subjects, ages 21-59 years (seven men, nine women) with panic disorder with or without agoraphobia were treated with an average of phenelzine 53.5 mg/day for an average of 10 weeks in an open treatment study. No significant effects on plasma levels of pyridoxal phosphate, the active form of vitamin B6, were discernible in this group, nor was there any clear relationship between pyridoxal phosphate levels and symptoms in the subgroup of five patients who did develop deficiency-type symptoms. Pyridoxine replacement had unclear effects in symptomatic patients.




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