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GABA , dopamine , Nardil vs. Selegiline / Emsam

Posted by Joe Schmoe on November 17, 2005, at 12:31:57

Can anyone clear up for me what the interaction is with GABA / dopamine, and how Nardil affects it vs. Selegiline (I am interested in MAOI drugs now because of Emsam).

I have read low dopamine levels are implicated in social phobia, as are low GABA levels and serotonin as well, and that is why Nardil works - it raises all three. Also I know benzos like Klonopin are used to treat low GABA levels and are used for social phobia.

But I have also read that GABA inhibits dopamine activity. I don't understand the theory behind raising both of them, or why raising just GABA (via Klonopin) would help if doing so lowers dopamine activity.

I am also curious if Selegiline / Emsam will affect GABA at all, or whether it will require Klonopin as well in order to combat social phobia. Nardil seems to work by itself. Does Selegiline require a benzo supplement to effectively treat social phobia? If so, what advantage would Selegiline and a benzo have over an SSRI and a benzo?





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