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Moclobemide dosage and pill frequency

Posted by Berty McNotBerty on November 17, 2005, at 9:24:19

Hello everyone, This is my fist post on Dr Bob but I've been a visitor for ages, it's cool so many people arte helpful and supportive.
But anyway, I've just started Moclobemide at 300mg per day & was wandering about dosage. I've heard that 300mg per day inhibits MAO-A by 80% so was wondering why peoples dosage can go up to 1200mg, all of the MAO-A would presumably be inhibited at dosages below that (I'm guessing). Also I've heard less dopamine is synthesised when MAO-A is inhibited by 80% or more. I was wandering if anyone knew therefore what benefits there would be of a dose of more than 300/450mg per day?

Another thing, Ive been considering adding low dose deprenyl to the 300mg moclobemide (after a couple of weeks depending on how the moclobemide goes) and I'm thinking of taking 5mg every other day (I've tried deprenyl on its own before but it increased anxiety). Are there any downsides to taking deprenyl on alternate days (or any sort of pills for that matter).




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poster:Berty McNotBerty thread:579587