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Half Live vs. Duration of Action

Posted by mike99 on November 12, 2005, at 9:16:32

Can anyone explain how dextroamphetamine has a plasma half-life of approximately 10 hours yet it's duration of action is only 4-6 hours?

For example, if one took 10 mg, wouldn't you then have the effect of 5 mg ten hours later?

I'm also curious how accumulation does not occur with a half-life over 5-6 hours or multiple daily dosings as my understanding is that 4-5 half-lives are required to eliminate a drug from the body.

Any thoughts on this?




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