Posted by sukarno on November 1, 2005, at 14:49:05
In reply to Developing side effects to tianeptine (Stablon), posted by sukarno on March 25, 2005, at 5:30:58
Stablon restores neurotrophic factor gene expression
A recent article entitled “Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments” , published in Biological Psychiatry by Alfonso J et al, confirms that the expression of numerous genes involved in the control of neuroplasticity, and particularly of genes coding for neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are significantly decreased in animals submitted to a paradigm of depression.
The authors measured the effect of a chronic (3 weeks) treatment with STABLON on the expression of genes involved in the regulation of neuroplasticity. The most remarkable finding was that STABLON is able to restore the expression of the genes for the neurotrophic factors BDNF and NGF (Figure 1).
These findings are in line with:
* the neuroplasticity hypothesis of depression according to which depression may result from alteration of neuroplasticity in brain areas involved in the control of mood and emotions.
* and with previously published data showing that STABLON has a unique impact on neuroplasticity. These new findings contribute to a better understanding of STABLON’s ability to restore neuroplasticity, and lend further support to its antidepressant efficacy.
Reference: Alfonso J, Frick LR, Silberman DM, Palumbo ML, Genaro AM, Frasch AC. Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments. Biol Psychiatry. Epub; October 2005