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Re: More Serzone questions...please help!

Posted by bigcat on September 26, 2005, at 10:48:03

In reply to The Dalhousie Seratonin Cocktail » bigcat, posted by EERRIICC on September 23, 2005, at 20:21:31

Thank you Eerriccc and Blueberry, I feel very informed after your replies. After years of a unbreakable, severe depression, responding to nothing except Nardil and Dexedrine, the last week on Serzone has been a roller coaster ride from hell. I was in full remission one afternoon, and in an agitated, excruciating depression by the next morning. That afternoon, I upped the dose 200mg and within hours, was having one of the best nights of my life, but now, even on a high dose +800mg, I'm doing horribly, worse than if I was on nothing at all.

Similar responses have occured before, when I have a great initial response to a med, but after a day or two it fizzles out completely and leaves me in such an acute depressive hell, the few hours of feeling good highlighting just how profoundly I suffer. I was wondering if this phenomenon would indicate what may be wrong with me chemically or treatment-wise and a strategy for finding a med and dose that works and keeps working. The remission I felt a few days ago was glorious, maybe I was slightly hypomanic, but the last four days have been such inescapapble hell, which no dosing changes seem to fix.

I went up to 1000mg after the push from 600-800 seemed to do wonders and then fade, and am back down at 600mg now. Am I too high, too low, or do I need to give the Serzone significantly more time to do it's thing properly? Soon after starting the Serzone, I had a great initial remission. When that faded, I moved the dose from 600 to 800, which brought a brilliant response within hours. Now I feel nothing at 1000, 800, or 600.

My only sucessful trials in the past have been MAOI's and stimulants, Nardil and dexedrine working beautifully for a couple weeks before fading out completely. I'd appreciate any advice or elaboration on your previous postings, which were already very helpful. Thanks.

-matt-


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