Posted by SLS on September 22, 2005, at 21:54:42
In reply to Re: effexor and remeron with opioid activity? » SLS, posted by Chairman_MAO on September 22, 2005, at 10:27:26
> Theories can be intellectually tasty, but they don't help depression much unless the drugs work. :(
Yup. Well said.
> You need a mu agonist, plain and simple. Bupe will do the trick; full agonists are better. If you have the option, go with oxymorphone. Tt is the most mood-brightening opioid IMHO. I really believe in the MAOI+opioid combination. Another advantage of bupe is that it is a kappa antagonist, which confers antimanic and antipsychotic properties, AFAIK. In addition, because it is a partial agonist, it seems to have a "normalizing" effect on the endorphin system that the full agonists don't. That is, tolerance to its mood-brightening effects don't seem to wane as much as with full agonists, although if you are an outright opioid responder this may not happen with full agonists, either. Its withdrawal syndrome is a walk in the park compared to even SSRIs.
I'll keep buprenorphine on my list of things to try. It's been on there for quite awhile, but I haven't placed it towards the top, mainly because I thought it would be difficult to convince my doctor to use it. As we move through trials, I think he will be more receptive to it.
- Scott
poster:SLS
thread:555898
URL: http://www.dr-bob.org/babble/20050921/msgs/558341.html