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Marplan and Steriod interaction? Need advice, Ed?

Posted by Tom Twilight on September 10, 2005, at 18:24:42

Hey everyone

I've encountered a problem that is to complex for me to solve, I'd apreciate the input of Ed or anyone else for that matter more knowlegable than me.

I suffer from Allergic Rhinitus which is really annoying
Beconase (Beclometasone dipropionate) nasal spray controls it effectivly.

However Beclometasone dipropionate is a hormone, this abstract seems to suggest that Glucocorticoids make Marplan less effective.
Unfortunatly the absract is to complex for me to fully understand.

Is Beclometasone dipropionate a Glucocorticoid? Could it interact?
Would Nardil also be affected?

Abstract

In recent years, the metabolism of isocarboxazid has become more clear. Rather than being metabolized by hepatic microsomal cytochromes or by hepatic acetylation, isocarboxazid is a specific substrate for and is hydrolyzed by RL2 hepatic microsomal carboxylesterase in rat liver microsomes. [6] Interestingly, this metabolizing enzyme is markedly induced by glucocorticoids and methylprednisolone. [7] This latter research convincingly demonstrated dose-dependent increased isocarboxazid hydrolase activity produced by dexamethasone. This finding may explain a clinical experience one of us (R.I.S.) had in the mid-1960s with a patient whose prednisone-induced anergic depression required increasing doses of isocarboxazid to maintain a positive clinical response even after discontinuation of the steroid.


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poster:Tom Twilight thread:553337
URL: http://www.dr-bob.org/babble/20050909/msgs/553337.html