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Re: what's the best treatment for agitated depression?

Posted by SLS on September 8, 2005, at 7:32:54

In reply to what's the best treatment for agitated depression?, posted by FredPotter on September 7, 2005, at 15:38:10

Hi Fred.

Tricyclics have been used to treat agitated depression in the past. It might be worthwhile giving one a try. Nortriptyline seems like the the best choice because of its milder side effects. Most people do well at 75mg. A gradual titration might help avoid an infrequent increase in anxiety or insomnia that can come in the beginning of treatment. Some people, on the other hand, feel calmer almost immediately. You might not need a particularly sedating tricyclic (amitripyline, doxepin, trimipramine) if you continue to use Zyprexa.

> I have inner restlessness, a sort of grinding of opposing forces inside me. I also have to fight off sleep all day. I therefore sleep excessively. I don't see any point in anything. I take lithium, Celexa 60mg and Zyprexa 2.5 mg. Can anyone recommend a better regime? I'd like to wash all the Celexa out and do a trial with Nardil or Selegeline. Do you think that's a good idea?

I think Nardil would be the better choice. It is more serotonergic (anti-obsessional) and GABAergic (anxiolytic). For now, I would try to maintain the Zyprexa.

- Scott




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