Posted by SJW on August 29, 2005, at 15:55:47
In reply to Calling Scott (SLS) and Emme-you'll be interested » SJW, posted by ed_uk on August 29, 2005, at 7:30:20
thanks for the welcome.
> What dose did you take and what side effects did you suffer? What other medications do you take?
It's been just over two years since I stopped the dextromethorphan cocktail. Let me preface this by saying that in hindsight my dosing schedule was irresponsible and dangerous... I found, for me, that 420mg dextromethorphan-polistirex was the minimum dose that had psychoactivity. At fisrt(about 3-4 days) the short-term memerory deficit was profound. I was already taking 20mg Adderall bid, 20mg famotidine bid, 2000mg Omegabrite(= approx 1250mg EPA & 550mg DHA) bid and 500mg niacinamide bid. I worked up to 600mg of dextromethorphan, then 720mg. When I hit 960mg(total remmision) my gait, then speech became noticably impaired and the urinary hesitancy was problematic. This is when I decided that I was doing more harm than good and ceased that protocol(after approx 4 wks in total). The negative effects luckily dissipated after 2-3 days and the antidepressant effect lasted approx 4-5 days.
I belive that MK-801,ketamine or PCP would have produced similar results, but that's pure speculation.
Also, on this regime I believe I felt a bit too good, slightly manic perhaps.
> Have you tried memantine and/or amantadine? - both NMDA antagonists
Yes, both. It was a few months later. First memantine, up to 30mg bid, didn't have much effect with or without Adderall. After two weeks I added sertraline for its SSRI and sigma receptor activity. I quickly worked up to 200mg q.d., but nothing positive transpired.
Amantadine, first alone 100mg bid for about five days. Then 200mg and finally 300mg bid over the peroid of about 3-4 weeks. Again the effect was mild, somewhat stimulating in a basic kind of way.
The rebound depression it produced on some days was not basic in its nature however. The Adderall
and sertraline didn't help.
I still have many more meds that I want to try.
Right now I take:
Parnate 40mg bid
Depakote 250mg bid
I have a theory(ies) as to why some NMDA antagonists have profound antidepressant activity, but now it's a matter of finding something else alone or in combination that can safely affect the same pathway(s).