Posted by Dave001 on August 29, 2005, at 3:52:06
In reply to Re: modafinil, posted by linkadge on August 28, 2005, at 16:52:59
> I'd like to see an article supporting its protection againts
> glutamate excitotoxicity. After all, does't the drug work primarily
> through enhancement of glutamatergic function ??
What I've seen of evidence for neuroprotection from modafinil has come
up incidentally in reading. One example: it partially reversed symptoms
of degeneration in a mouse model of Huntington's disease when
administered in combination with creatine monohydrate and another
substance (the name of which escapes me at the moment).
I haven't evaluated the evidence enough to have formed any opinion on
the matter; I had mentioned the possible neuroprotective properties to
assuage the poster's concern that he was causing himself harm, because
if anything, the evidence points in the opposite direction.
Here are several citations from a quick PubMed search:
Aguirre, J. A., A. Cintra, et al. (1999). "A stereological study on the
neuroprotective actions of acute modafinil treatment on
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral lesions of
the male black mouse." Neuroscience Letters 275(3): 215-8.
Antonelli, T., L. Ferraro, et al. (1998). "Modafinil prevents glutamate
cytotoxicity in cultured cortical neurons." Neuroreport 9(18): 4209-13.
Jenner, P., B. Y. Zeng, et al. (2000). "Antiparkinsonian and
neuroprotective effects of modafinil in the mptp-treated common
marmoset." Experimental Brain Research 133(2): 178-88.
Xiao, Y.-l., J.-m. Fu, et al. (2004). "Neuroprotective mechanism of
modafinil on Parkinson disease induced by
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine." Acta Pharmacol Sin 25(3):
Zeng, B. Y., L. A. Smith, et al. (2004). "Modafinil prevents the
MPTP-induced increase in GABAA receptor binding in the internal globus
pallidus of MPTP-treated common marmosets." Neuroscience Letters 354(1):
* You can download the full text to the corresponding study here for free:
I'm sure there are plenty more if you want to track them down.