Posted by zeugma on August 28, 2005, at 17:00:36
In reply to Re: modafinil, posted by linkadge on August 28, 2005, at 16:52:59
> I'd like to see an article supporting its protection againts glutamate excitotoxicity. After all, does't the drug work primarily through enhancement of glutamatergic function ??
There is one, actually:
Neuroreport. 1998 Dec 21;9(18):4209-13. Related Articles, Links
Modafinil prevents glutamate cytotoxicity in cultured cortical neurons.
Antonelli T, Ferraro L, Hillion J, Tomasini MC, Rambert FA, Fuxe K.
Department of Experimental and Clinical Medicine, University of Ferrara, Italy.
The ability of modafinil (Modiodal) to protect cortical neurons from glutamate-induced degeneration was evaluated by measuring electrically evoked [3H]GABA release and [3H]GABA uptake in primary cerebral cortical cultures. In normal cells, electrical stimulation (10 Hz, 2 min) increased [3H]GABA release (FR-NER St1 = 0.77+/-0.14; St2/St1 ratio = 0.94+/-0.02). The exposure of sister cells to glutamate, reduced electrically evoked [3H]GABA release (FR-NER St1 = 0.40+/-0.05; St2/St1 ratio = 0.60+/-0.08). Modafinil (0.3-1 microM) prevented the glutamate-induced reduction of the St2/St1 ratio (0.85+/-0.11; 0.88+/-0.05, respectively). A similar protective effect was observed for [3H]GABA uptake. These findings suggest that modafinil may be neuroprotective in that it attenuates glutamate-induced excitotoxicity in cortical neurons.
it would be comforting to think that this was conclusive.