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Re: BDNF Question

Posted by linkadge on August 24, 2005, at 16:51:55

In reply to Re: BDNF Question » denise190466, posted by Jedi on August 24, 2005, at 12:01:43

I would hazzard to *slightly* disagree with the above post. The TCA's can provide some degree relief very quickly due to their profile.

First they are potent anticholinergics. Anticholinergics are fast acting antidepressants. Infact single injections of anticholinergics in mice increases dopamine in the neuculeus accumbens. Anticholinergics are rewarding, and that is why some people abuse potent anticholinergic drugs like cogentin.


Second, their 5-ht2a blocking potential can lower cortisol immediately.

Third, they have strong effects on the opiate system, that work immediately. Opiates like heroin, relive depresson immediately.

The antihistamine effects can also relieve some anxiety.


The neurotrophic effects of the meds would certainly take longer to kick in, that does not mean they cannot provide some subjective relief quickly.


Linkadge



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