Posted by SLS on August 21, 2005, at 7:04:05
In reply to Re: Why does lamictal poop out ? » linkadge, posted by ed_uk on August 21, 2005, at 6:26:37
> Hi Link,
> >ARe lamical's effects in epilepsy also so variable, and short lived ?
> No, apparantly not.
I have always had a suspicion that there was something dopaminergic going on with Lamictal, although not necessarily directly. I think it is here that the drug produces its short-lived mood-brightening effects. Lamictal seems to like to work in combination with other drugs, although I would not yet be able to characterize them. Perhaps NMDA antagonists would be helpful in extending the therapeutic effects of Lamictal. Memantine and dextromethorphan come to mind. Of course, dextromethorphan cannot be combined with an MAOI.