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Re: Do SSRIs work? » FredPotter

Posted by tecknohed on August 5, 2005, at 17:49:54

In reply to Do SSRIs work?, posted by FredPotter on August 4, 2005, at 22:03:34

I personally have never done well on any drug which directly manipulates serotonin at the synaps. I've tried all SSRIs (except fluvoxamine), Venlafaxine, Clomipramine, Nefazodone and Mirtazepine. With these drugs I ended up feeling lethargic, apathetic and slept excessively. And yet in most doctors minds my symptoms (Social Anxiety, Depression and OCD, etc) would clearly indicate the use of an SSRI.

Nardil did help me a lot, but works 'indirectly' on Serotonin through MAO inhibition, as well as having effects on other neurotransmitters(dopamine, noradrenalin, GABA). Mind you, I still became excessively tired on it.

Yet SSRIs work for some. Especially those with OCD. Also, women seem to benefit from them more than men (dont quote me on that).


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