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Re: Anyone take Ultram for psychiatric use? Jakeman

Posted by ace on July 21, 2005, at 1:23:04

In reply to Re: Anyone take Ultram for psychiatric use?, posted by Jakeman on July 18, 2005, at 21:10:39

> Some people do. Check the posts above and in the archives for tramadol. What is your experience with Ultram?
> warm regards ~Jake
> Effects of chronic tramadol on pre- and post-synaptic measures of monoamine
> function.
> Hopwood SE, Owesson CA, Callado LF, McLaughlin DP, Stamford JA.
> Academic Department of Anaesthesia and Intensive Care, St Bartholomew's and
> The Royal London School of Medicine and Dentistry, Royal London Hospital,
> Whitechapel, UK.
> The atypical analgesic tramadol has strong structural similarities to the
> antidepressant venlafaxine and is a mixed noradrenaline (NA) and serotonin
> (5-HT) uptake inhibitor. Because tramadol has been found active in the
> forced swim test, a common predictor of antidepressant efficacy, we
> therefore examined the effects of chronic tramadol on various pre- and
> post-synaptic monoamine measures. Male Wistar rats (150-200 g) received
> tramadol (20 mg/kg i.p.) or vehicle for 21 days and were sacrificed 24 h
> after the last dose. Quantitative autoradiography revealed that specific
> frontocortical [3H]dihydroalprenolol and [3H]ketanserin binding was lower in
> the chronic tramadol group than controls (beta: 37+/-8 and 217+/-56 fmol/mg;
> 5-HT2A: 23+/-3 and 44+/-7 fmol/mg, respectively, p < 0.05). Chronic tramadol
> had no effect on the magnitude of electrically stimulated noradrenaline (NA)
> efflux or uptake in locus coeruleus (LC) slices. Although dexmedetomidine
> (10 nM) decreased LC NA efflux equally (by approximately 60%) in chronic
> tramadol and vehicle groups, desipramine (50 nM) increased LC NA efflux more
> in vehicle (to 164+/-7%) than tramadol-treated rats (144+/-6%; p < 0.05).
> Chronic tramadol had no effect on dorsal raphe (DRN) or median raphe (MRN)
> 5-HT efflux. However, 5-HT uptake in tramadol-treated rats was slower (p <
> 0.05) in MRN and nearly so (p = 0.055) in DRN. The selective 5-HT1A agonist
> 8-OH-DPAT reduced 5-HT efflux in both DRN and MRN. Its effect in DRN was
> greater in rats given chronic tramadol than in vehicle controls (54+/-2
> versus 32+/-6% reduction in 5-HT efflux, respectively). In conclusion, we
> suggest that tramadol has many of the pre- and postsynaptic neurochemical
> features of a conventional antidepressant, as might be predicted from its
> pharmacology.

BE CVERY CAREFUL with Tramadol (Ultram) I used it for 3 /4 weeks every second day or so. Tolerance builds quickly. It put me in a state of bliss (Mu-Opioid stimulation) but the rebound depression was hell. One night of bliss isn't worth two days of hell in bed...





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