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Re: D-2 blockade, Akathisia, Amantadine, Smoking cache-monkey

Posted by ed_uk on July 19, 2005, at 17:38:53

In reply to D-2 blockade, Akathisia, Amantadine, Smoking ed_uk, posted by cache-monkey on July 19, 2005, at 1:04:55

Hi,

>Out of curiosity, how, exactly, does it feel for you when your D-2 receptors get blocked?

Absolutely dreadful. I had to go to the ER after I took Thorazine. I needed 60mg Valium to calm my agitation and akathisia. I was writhing. I wished I was dead. I felt overwhelming panic and extreme motor restlessness. I couldn't be still for more than a second. I felt awful from head to toe, like my muscles were going to explode. I couldn't think normally either, I felt quite confused.

>Amantadine actually made me feel worse.

Have you tried an anticholinergic? I'm not recommending it I'm just curious. I think it would be better to d/c the AP if it isn't helpful at a lower dose.

>One thing I'm worried about, though: does agonising the a receptor lead to down-regulation?

It can do. I'm not sure whether this applies to the D2 receptor though.

Kind regards

~Ed


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