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D-2 blockade, Akathisia, Amantadine, Smoking ed_uk

Posted by cache-monkey on July 19, 2005, at 1:04:55

In reply to Re: AP Akathisia ... does it go away?? Amant. helpful? cache-monkey, posted by ed_uk on July 17, 2005, at 15:40:45

<< It sounds like D2 antagonism just isn't what you need. It's certainly not what I need! I even get akathisia from Phenergan, an antihistamine with weak D2 antagonism. It makes me feel absolutely dreadful! >>

It's good to know that I'm not alone here. Out of curiosity, how, exactly, does it feel for you when your D-2 receptors get blocked?

For me it's this very energetic, kinetic kind of anxiety. I find it really hard to keep my mind still, and I feel very negative about everything (almost a sense of impending doom, or maybe hopelessness).

Amantadine actually made me feel worse. Even more energized, but negatively and wholly unable to focus. I'm now on my second day of the lower dose of Geodon and might be feeling a little better. Too early to tell, though.

Actually, given that one of my main treatment goals is to quit smoking, Geodon might be a bad thing. I read this study comparing Haldol-Bromocriptine-placebo. The upshot was that Haldol (D-2 blocker) increased smoking behaviour, while Bromo (D-2 agonist) reduced it.

One thing I'm worried about, though: does agonising the a receptor lead to down-regulation? I.e. if I take bromocriptine to quit smoking would I have problems after withdrawing the drug because I have still fewer D-2 receptors?

If you have a moment, I'd appreciate your thoughts.





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