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Lamictal and the contraceptive pill

Posted by ed_uk on July 15, 2005, at 15:03:36

Updated advice for women on lamotrigine and the pill

Prescribing information for lamotrigine (Lamictal) has been updated following new data showing that the drug interacts with combined oral contraceptives.

GlaxoSmithKline, the product’s manufacturer, has sent a letter to health care professionals informing them that taking lamotrigine with oral contraceptives may result in reduced effectiveness of the contraceptive, and that the use of effective non-hormonal methods of contraception should be considered.

Reduced seizure control may occur in women on a stable dose of lamotrigine who start on an oral contraceptive, GSK warns, and the maintenance dose of the antiepileptic may need to be doubled. Similarly, following withdrawal of an oral contraceptive the dose of lamotrigine may need to be reduced by as much as 50 per cent to avoid adverse effects.

GSK also says that lamotrigine levels may decrease during pregnancy and quickly revert after delivery, so women taking the drug must be closely monitored during and after pregnancy.



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