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Re: difference between auto- and heteroreceptors linkadge

Posted by Shawn. T. on July 14, 2005, at 19:34:17

In reply to Re: difference between auto- and heteroreceptors, posted by linkadge on July 12, 2005, at 20:00:37

Persistent agonist activity at an autoreceptor can result in a decrease in the amount of membrane-associated G(alpha)i. G(alpha)i inhibits adenylate cyclase, an enzyme that catalyzes the formation of cyclic AMP (cAMP) from ATP. Persistent agonist activity at G(alpha)i coupled receptors may also result in a sensitization of adenylate cyclase, which would lead to an increase in cAMP formation. The mechanisms involved are more complicated than that, and they still aren't fully understood yet. Decreased extracellular serotonin levels can increase the sensitivity of serotonin autoreceptors.





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