Posted by ed_uk on July 8, 2005, at 13:47:34
In reply to Re: Distress Signals from the UK, posted by Tom Twilight on July 7, 2005, at 15:30:23
>I've already started the Marplan/Isocarboxazid.......
Any side effects so far? ....on your little dose!
>I'm just depressed because its so expensive........
It's a rip off. Nardil is much cheaper. Hopefully your NHS GP will prescribe your medication once you're on a stable dose etc.
Here are the net prices (not what you pay at the pharmacy....but useful for comparison)........
Nardil. Twenty 15mg tabs £3.99
Isocarboxazid. Fifty 10mg tablets £27.79
Tranylcypromine (Parnate). Twenty-eight 10mg tablets £5.08
>Do you have any idea about the half-life of Isocarboxazid.......
I don't know. The half-life of an irreversible MAOI is not relevent to it's duration of action. To be honest, it's not a particularly useful parameter to know. AFAIK, isocarboxazid it converetd to one or more active metabolites that are responsible for it's therapeutic activity.
Oh look, I just found this.......
'The plasma half life of isocarboxazid is about 2.5 hours and is unrelated to the duration of enzyme (MAO) inhibition.'
>...its so obscure I can't even find that out!
It's very obscure, much more so than Nardil!
>To be fair he was the most well informed UK doc I've met.
The fact that he'd heard of isocarboxazid is a good sign :-)
>I don't think that Marplan works for SA.......
I think there's an excellent chance that it will work. If it doesn't, you can try something else :-)