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Re: Switching MAOIs

Posted by willyee on July 3, 2005, at 12:47:10

In reply to Switching MAOIs, posted by JochenK on July 3, 2005, at 5:56:10

> Are there any precautions to be taken when scwitching from one MAOI to another (e.g. from Parnate to Nardil)? Does there have to be a medication-free period like with other ADs?
>
> Jochen

Might wanna research the archives,i cant recomend this directly to u as it is technicaly contradicted,BUT quite a few people have switched over without a washout.

SSri to maoi is def something u wanna washout from,and even with maois nardil might be a problem.

Parnate however is now being considered reversable,parnate states its effect wears off in a couple of days,but a direct effect seems to be dependent on daily dosing,and usualy in 4-5 hours a DIRECT effect isnt there.

What im saying basicaly is most people dont have a problem switching from parnate to nardil with little washout perhaps a day.

One benifit i personaly can vouche for in doing this is,nardil unlike parnate takes a lil time to work,so if u washout from parnate,high proability is u will hit a W/D,you will feel very lousy period and it will be that much hard to tolerate nardil or any other med that doesent bring IMMEDIATE reliaf since ur in a W/D.

Switching while ur in a somewhat stable state from parnate as in a few peoples case i know of might make the transition less difficult.

Id read some of chairmans posts who did just that,as well as a few other archived posts to see if u might wanna try this,as well as see that ur doc thinks.

Also before anyone says anything,lol do a search for keywords parnate,reversable and u will see some data sheets are now stating parnate is believed to be reversable.


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