Posted by Elroy on June 29, 2005, at 18:54:46
In reply to Anti-Cortisol Therapy: metyrapone and ketoconazole, posted by SLS on June 29, 2005, at 6:28:35
Am aware of ketoconazole but endo is highly against prescribing it due to adverse side effects.
I believe that the key will end up being the drug RU486 but (even though it's been "fast tracked" by the FDA) it's approval progress has been moving very slowly.
With RU486 the protocol is a very short-term regimen (studies I've seen have been in the four to seven day range). Cortisol lowered, HPA Axis re-set and anxiety / depression problems either resolved or (if especially resistant) now quickly respond to standard treatments.
Elroy
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X> For those people living in the UK, there is an antiglucocorticoid named metyrapone that is used to treat Cushings Syndrome and other hypercortisolemic conditions. I believe metyrapone is also available in Canada. I hope someone can check on this.
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> Unfortunately, in the US, metyrapone is used only as a test for diagnostic purposes. It helps to differentiate the status of the adrenal glands versus the status of the HPA axis.
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> Ketoconazole is a cortisol synthesis inhibitor that might be of use for some people.
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> - Scott
poster:Elroy
thread:515432
URL: http://www.dr-bob.org/babble/20050627/msgs/521211.html