Posted by Ron Hill on June 18, 2005, at 14:49:04
In reply to Re: History of emsam as I know it » yldouglas, posted by chemist on May 11, 2005, at 21:31:06
> the MAO-A/B switch that you mention is a mystery: the drug is an MAO-B inhibitor as low doses, and a dopamine uptake inhibitor at high doses.
Do you have any pharmacological research data that support the claim that Selegiline is a dopamine uptake inhibitor at high dosages and that it is not an MAOI-A? The medical research data repeated state that Selegiline is a selective MAOI-B up to a dosage of about 15 - 20 mg/day at which point it loses its selectivity and becomes an MAOI-A and an MAOI-B.
Therefore, please post the link(s) that support the claim that Selegiline is a dopamine uptake inhibitor at high dosages and not an MAOI-A.
BP II and OCPD
600 mg/day Lithobid
900 mg/day Trileptal
50 mg/day Lamictal (level limited by rash)
5 mg/day Deprenyl (as tx for atypical depression)