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Re: Selegiline Pharmacology » St James » Oracle » chemist

Posted by Ron Hill on June 18, 2005, at 14:49:04

In reply to Re: History of emsam as I know it » yldouglas, posted by chemist on May 11, 2005, at 21:31:06

> the MAO-A/B switch that you mention is a mystery: the drug is an MAO-B inhibitor as low doses, and a dopamine uptake inhibitor at high doses.

Do you have any pharmacological research data that support the claim that Selegiline is a dopamine uptake inhibitor at high dosages and that it is not an MAOI-A? The medical research data repeated state that Selegiline is a selective MAOI-B up to a dosage of about 15 - 20 mg/day at which point it loses its selectivity and becomes an MAOI-A and an MAOI-B.

Therefore, please post the link(s) that support the claim that Selegiline is a dopamine uptake inhibitor at high dosages and not an MAOI-A.

-- Ron

BP II and OCPD

600 mg/day Lithobid

900 mg/day Trileptal

50 mg/day Lamictal (level limited by rash)

5 mg/day Deprenyl (as tx for atypical depression)


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URL: http://www.dr-bob.org/babble/20050617/msgs/515017.html