Posted by ed_uk on June 18, 2005, at 9:33:11
In reply to Re: forget my last post!, posted by KaraS on June 18, 2005, at 3:34:12
>Would the sublingual selegiline also obviate the need for the MAOI diet?
Well.....it's only been studied at low doses - where dietary restrictions are unnecessary anyway. I'd expect sublingual seleg to potentiate the hypertensive effect of tyramine to a lesser extent that oral seleg because most of the seleg will bypass the gut when absorbed via this route. I suppose you'd have to be careful not to swallow any though!
I can't say the diet would be unnecessary with a high dose but I expect the chance of a hypertensive reaction would be somewhat reduced.
The bioavailability of the sublingual tablets is not the same as the oral tablets. For Parkinson's disease, the recommended dose of Zelapar is 1.25mg/day, as opposed to 10mg for the oral tabs.
RE the abstract from Prescrire Int. The journal is negative about EVERYTHING! I'm not kidding! I think they're just interested in health economics really.