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Re: Seroquel Pharmacology question » chess

Posted by ed_uk on June 7, 2005, at 11:43:58

In reply to Seroquel Pharmacology question, posted by chess on June 7, 2005, at 10:09:13

Hi Chess,

>serotonin 5-HT2 occupancy fell even more slowly (half-life, 20 - 27 h)

Occupancy (and therefore antagonism) of 5-HT2 receptors dropped by half after 20-27 hours.

>D2-receptor occupancy declined more slowly (half-life, 6 - 6.4 h)

It's action at D2 receptors may also be important for its anxiolytic effects.

>.......and thus that Seroquel can be taken once-a-day for anxiety?

It might be effective once daily- you'll have to try it and see!

Are you concerned that you might forget to take it if you had to take it more than once daily?

Kind regards,
Ed.


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poster:ed_uk thread:509023
URL: http://www.dr-bob.org/babble/20050606/msgs/509059.html