Posted by Maxime on June 6, 2005, at 20:11:39
In reply to Re: Neurontin to Topomax » ed_uk, posted by Larry Hoover on June 6, 2005, at 19:58:07
Hi Larry. I take Trileptal and the nausea and dizziness went away in about a week. Plus I take it at night so it wasn't too much of an issue. Tegretol I couldn't even walk straight on. I've been on all the mood stabilisers available in Canada and Trileptal has been the best one for me in terms of effect and side effects.
Maxime
> > Hi Lar,
> >
> > >Having had the good response to the other non-opioid agents, though, I wonder if that's the best strategy.
> >
> > You could try another antiepileptic!!
> >
> > About Trileptal........
> >
> > J Pain Symptom Manage. 2003 May;25(5 Suppl):S31-5.
> >
> > Rationale and evidence for the use of oxcarbazepine in neuropathic pain.
> >
> > Carrazana E, Mikoshiba I.
> >
> > Neuroscience, Clinical Development and Medical Affairs, Novartis Pharmaceuticals, East Hanover, NJ 07936-1080, USA.
> >
> > Oxcarbazepine is a second-generation antiepileptic drug (AED) with proven efficacy in managing partial epileptic seizures, with or without secondary generalization, in adults and children. The overlap between the underlying pathophysiologic mechanisms of some epilepsy models and neuropathic pain models supports the rationale for using certain AEDs in the treatment of neuropathic pain. Several AEDs have reportedly produced analgesia in a range of neuropathic pains, including painful diabetic neuropathy (PDN) and post-herpetic neuralgia. Increasing evidence suggests that oxcarbazepine can provide significant analgesia in several neuropathic pain conditions, including trigeminal neuralgia and PDN, and is also may be effective in treating neuropathic pain refractory to other AEDs, such as carbamazepine and gabapentin. The analgesic effects of oxcarbazepine, and its generally improved safety and tolerability profile compared with other standard AEDs, suggests that oxcarbazepine will be an important addition to the neuropathic pain armamentarium. The rationale and evidence to support the efficacy of oxcarbazepine are presented here.
> >
> > Kind regards,
> > Ed.
>
> I really appreciate the effort, Ed.
>
> When I checked the monograph for Trileptal, however, the frequencies for e.g. nausea and dizziness are greater for this med than for Topomax. How does that come through as being more tolerable?
>
> Lar
>
>
poster:Maxime
thread:508502
URL: http://www.dr-bob.org/babble/20050606/msgs/508794.html