Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Melatonin safe with MAOIs? » cybercafe

Posted by Larry Hoover on May 20, 2005, at 17:58:41

In reply to Melatonin safe with MAOIs?, posted by cybercafe on May 20, 2005, at 14:43:56

> Hey guys... I am sleeping at the strangest hours. Find it really hard to sleep when I should. Want to try melatonin..
>
> I am also taking parnate 30 mg / day.
>
> Can I combine the two?

Yes.

The effective dose of melatonin, though, can vary by an order of magnitude, across individuals. And, unlike other drugs, melatonin has an inverted-U shaped dose-response curve. If you know what the standard bell-curve looks like, it's something like that.

At lower (relative) doses, response increases with dose (kind of what you'd expect). Then, you reach a plateau. Increasing dose does not increase the effect. Then, at even higher doses, the response drops off (the opposite of what you'd expect).

The thing you need to do is figure out what your plateau dose is, and never exceed that.

Normal physiological amounts of melatonin are about 0.6 mg, yet the standard tablets are 3 mg. It could be that some people don't absorb it well, or their livers degrade it, or whatever....so you need to experiment with dose.

If you start at around 0.75 mg (1/4 tablet) and work up by quarters, you should find your dose without exceeding it. (If you go too high, nothing will happen at all.)

My own effective dose is in the 0.6 to 1.0 mg range. I've heard of people needing 6 mg or more.

Best,
Lar

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Larry Hoover thread:500404
URL: http://www.dr-bob.org/babble/20050516/msgs/500488.html