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Re: Weight gain - but is Clozapine my last shot?

Posted by med_empowered on May 17, 2005, at 21:50:17

In reply to Re: Weight gain - but is Clozapine my last shot?, posted by Phillipa on May 17, 2005, at 18:32:09

Hey! I don't wanna rain on your parade, but are you **sure** clozapine is the way to go? I mean, if you **must** take an anti-psychotic, and your only choices now would be clozpine or an old drug, like Mellaril or something, I'd say go for the clozapine. But...clozapine is some rough stuff. I've known a few people on it. In addition to the blood tests, you have the weight gain potential. There's sometimes drooling (I've seen it ...not pretty). There's **dense** sedation (I had a friend who would fall asleep in the middle of a card game) and, of course, there is the unusually large risk of drug-induced seizures. In fact, one of the people I knew who took it was given Depakote specifically to prevent clozapine-induced seizures. He didn't have any seizures...but the combined effect made him kinda stupid. Plus, clozapine doesn't play well with other drugs, even ones commonly used for schizophrenia/schizoaffective/bipolar. Benzodiazepenes, for instance, are very, very rarely used with clozapine b/c of some freaky side effect (I wanna say some sort of liver thing, but I'm not sure). BUT clozapine has helped many people live happier, healthier, more fulfilling lives...I'm just trying to point out that anti-psychotics in general, and clozapine in particular, are still pretty hardcore meds in terms of side-effects. Good luck!




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