Posted by franco neuro on May 13, 2005, at 21:43:19
In reply to Re: On the ketamine note ... » franco neuro, posted by ed_uk on May 13, 2005, at 11:30:32
> What type of pain do you suffer from? I think you mentioned that you used to take amitriptyline but it was too sedating. Have you tried desipramine or nortriptyline?
I suffer from neuropathic pain. It's mostly on my left side. Nerve pain and weekness in my left leg and foot and visceral and pelvic pain. I wish I had taken desipramine instead of amitriptyline. It's a much "cleaner" med. All the time I was taking it I thought it was it's antihistamine action that was putting me to sleep. But I've come to realize it wasn't. I've tested various antihistamines and I don't find them sedating at all. They are somewhat analgesic as far as the visceral pain goes. I had to keep upping the dose of amitriptyline over the course of the three and a half years I was on it. I must have really been propping up my NE levels because when I stopped it I really went down hill fast. It was like the bottom dropped out. I felt like my muscles were melting away. It was pretty horrible. I still haven't recovered over two years later. Right now I'm trying to find the right cocktail. Neurontin has helped a lot with the peripheral pain. And the first day I took bupropion SR I felt a sense of relief all over the left side of my chest and torso. There was just a feeling like it was filling up this painful hollowness (if that makes any sense) on my left side. Ufortunately, it started to knock me out. I know there is a large NE componant to my problems. But I'm trying to pinpoint exactly which NE receptors. I'd like to give Clonidine a shot. It's stimulates the alpha-2 receptor and has some other interesting properties.