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Re: Effexor and alcohol use and thoughts » Kotari

Posted by Mr.Scott on May 7, 2005, at 9:18:23

In reply to Re: Effexor and alcohol use and thoughts, posted by Kotari on May 6, 2005, at 13:15:47

Hi,

I've never heard anyone report improved sex drive from Effexor at any dose. Perhaps if you're near incapacitated, any antidepressant will help but wellbutrin is reportedly more likely than Effexor to achieve this. Don't expect much dopamine action from Effexor and certainly not until around 300mg. However, wellbutrin made 'me' climb the walls while amphetamine does not!! Effex might be causing the headaches, these meds elude even their manufacturers understanding. If the headaches are new it probably is the cause.

In a nut shell...increasing serotonin inhibits the action of dopamine in the nigra-striatal region of the brain (differently for everyone, and with varying sensitivities). In this region dopamine acts as an 'inhibitory' neurotransmitter over acetycholine. This region is frequently associated with movement among other things. Through this cascade of increasing serotonin leading to decreased dopamine and increased acetycholine 'can' a person experience akathisia and other EPS symptoms. Not common from ssri/snri's but it does happen. When it does think of parkinson's symptoms, and related changes in muscle tone or rigidity, restlessness, etc.

But I would say if you can't tolerate the side effects of a higher dose, or/and you feel you need more antidepressant action you should talk to your doc. Thats what they get paid for.

To listen to us whine and ask for pills :-)!

> Scott,
>
> I did experience akasthesia on the low dose of zyprexa - literally could not sit still and wanted to jump out of my skin. It would only last for 15-20 mins., but very uncomfortable. Never had anything like that with the effexor, but I recently have been trying to increase my dose above 75 mg. and have been nervously chewing my fingers to bits. Very unattractive.
>
> I am interested in what you said about DOPAMINE. The psych who wanted me to increase the effexor said I would get more dopamine with the higher dose and my sex drive would improve. I think that increasng the dose has caused the migraines. Did not know that low dopamine could cause that restlessness problem. Are there other effects that you know of?
>
> I am seriously considering asking to doc to add wellbutrin to my mix, to see if I can increase dopamine that way.
>
> Anyone else out there take this mix? I'm also taking trazadone at night and it would be great to be able to skip this and still be able to sleep.
>
> Kotari
>


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