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Re: Nardil and Parnate in lower doses » Declan

Posted by cubbybear on May 6, 2005, at 10:08:57

In reply to Re: Nardil and Parnate in lower doses Joe1, posted by Declan on May 6, 2005, at 8:58:36

> Why would that be? I'd always thought it was a question of strength. What do Marplan and Parnate have in common in their therapeutic profile?
> Declan

I don't think that "strength" is a term used in the clinical sense,although I guess that if a person found one AD very helpful, to him/her it would be stronger than one which was only partially helpful.

As for Parnate and Marplan, when I researched and compared the two (as well as Nardil) , I looked at efficacy vs. my own depression symptoms such anxiety, loss of appetite, premature sleep awakening, etc. (To this day I don't know if my unipolar depression would be labelled endogenous, abnormal, or whatever labels DSM has got. I seem to have some symptoms from one kind of depression and some symptoms from another.)

However, It appears from my research that Marplan definitely has more suitability compared to Nardil for my kind of depression.

I also researched side effects of all three MAOIs, and it seems that the side effect profile of Marplan is more benign and tolerable than that of Nardil. Conversely, some of the side effects/problems I've seen reported with Nardil got me concerned, such as higher risk of liver toxicity and somewhat greater likelihood of hypertensive crisis on Nardil.

Maybe I'm just being paranoid but I don't trust the drug companies, especially Glaxo Smith Kline, mfr. of Parnate, and I thought, what MAOI would I fall back on *if* Parnate was ever discontinued or impossibly expensive? the answer for me was Marplan.

So briefly, I based my comment just on researching published reports and comparisons.
I hope this answers your question.





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