Posted by chemist on April 30, 2005, at 0:52:20
In reply to Re: how long do benzos work? - chemist, posted by lgmg on April 29, 2005, at 6:30:57
> i've been on lorazepam and i've always wondered if alprazolam might work better, do you hve any thoughts on the difference?
hello there, chemist here...matt is correct in that i will happily spill the intricacies of subunit binding domain differences for the GABA A, B, and C LGICs if you like...matt's post is one that makes me think that he should open up a practice near my home: they truth balanced with practical aspects that obviously enter on the side of the prescribing m.d. (``do i have to worry about this patient drinking alcohol with their xanax or is the dose escalation speeding along?'' etc.)....
the anti-depressant effects of triazolo- derivs. of benzos are documented but the drugs are not used to combat depression alone, obviously, thus any effect will augment. likewise, if the benzo is more sedating - diazepam is commonly thought of in this light - then you will be, yes, a little more tired and perhaps ``down.''
if you take a drug p.r.n. for panic, diazepam beats lorazepam for onset - this is a property of the substances - but lorazepam has more pronounced action. alprazolam is a quick sledgehammer in my opinion and experience: i take it and have taken numerous benzos and with minor dose adjustment, i could swap one for another. BUT we are talking chronic use.
which brings me to matt's post. if think the change from lorazepam to alprazolam would be ill-advised unless you are having breakthrough panic or finding that your consumption is getting out of hand. that said, i doubt any reasonable doctor would switch a person from lorazepam to alprazolam if the patient was appearing to become a little more fond of benzos than one should.
do let me know if you wish a discourse concerning the vageries of ligand binding domains and conformational analyses of changes in large proteins upon binding of substrate: i will bore the audience with vigor....all the best, chemist
poster:chemist
thread:488862
URL: http://www.dr-bob.org/babble/20050428/msgs/491773.html