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Re: Chemist...Seroquel...hlp please.. » jay

Posted by chemist on April 26, 2005, at 22:45:17

In reply to Chemist...Seroquel...hlp please.., posted by jay on April 26, 2005, at 13:56:16

> Hi Chemist:
>
> Sorry to bug...I know you are a busy person..but in a post above you said something to the effect that Seroquel 200-300mg+ has less sedation and type side effects than below that dose. If you don't mind me asking, do you have a reference to this? (i.e. a study or something similar.) It's just that I do sort of see this, as 25-100mg used to knock me out into 15 or so hours of restless, horrible, constant rem sleep. I am finding at the 200-300 mg level, those side effects seem less pronounced. I still fall asleep quite quickly, but am able to get up without feeling like I've been run over by a truck. For the original reasons, I wrote Seroquel off as having any use, but may be now changing my mind, as it seems to have consistent sedation when taken, without the problems of Zyprexa, and seems much stronger than Risperdal. Any comments please...thank you so kindly...
>
> Jay :-)

hello there, chemist here...i am the one usually doing the bothering: it's my calling!...the other posters who replied are, i believe, supportive of the seroquel phenomena. as for references, i am in short supply in re: quetiapine. i have aprox. 25 manuscripts in my general mood disorders files, and they are largely comparisons of the newer off-label drugs for BP vs. lithium and valproate. however: see keck and mcelroy (2002), j. clin. psychiatry 63 (suppl 4), pp. 3-11. be wary of this journal: almost every article emanates from ``unrestricted educational grants from'' insert pharma here. there are facts lurking, however, and this is a review-style paper. you can barely tell that lilly funded the research. anyhow, the drug hits a slew of receptors, including D_{1}, D_{2}, M_{1}, 5-HT_{1A} (weak affinity); and higher affinity for H_{1}, 5-HT_{2A/2C}, and alpha_{1} and alpha_{2}. the sedation is logically attributed to H_{1} and alpha_{1}, and the antimanic effects will be mostly with D_{2}, and some antidepressant with the remainder. mechanism? i don't know, and i suspect that given the high affinity for the histamine and alpha_{1} receptors that they get saturated first, and with higher doses, the other holes get plugged and the sedation is counteracted in a way....linear kinetics, and not much else i can tell you except that i will look into it further and that it was quite an effective drug for helping with sleep at the time....all the best, chemist


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