Posted by cache-monkey on April 26, 2005, at 21:51:18
In reply to Chemist...Seroquel...hlp please.., posted by jay on April 26, 2005, at 13:56:16
I'm wondering what this means in terms of ramping up the dose to 200-300 mg. I.e. does the sedation just diminish at higher doses? Or is it that one develops tolerance over the period of titration?
I've actually heard the second argument, and that the tolerance to the sedation is accomplished more quickly the faster one titrates up.
However, if it is simply a dose-related thing, I would definitely like to hear more about the mechanism at work.
Best,
cache-monkey
> Hi Chemist:
>
> Sorry to bug...I know you are a busy person..but in a post above you said something to the effect that Seroquel 200-300mg+ has less sedation and type side effects than below that dose. If you don't mind me asking, do you have a reference to this? (i.e. a study or something similar.) It's just that I do sort of see this, as 25-100mg used to knock me out into 15 or so hours of restless, horrible, constant rem sleep. I am finding at the 200-300 mg level, those side effects seem less pronounced. I still fall asleep quite quickly, but am able to get up without feeling like I've been run over by a truck. For the original reasons, I wrote Seroquel off as having any use, but may be now changing my mind, as it seems to have consistent sedation when taken, without the problems of Zyprexa, and seems much stronger than Risperdal. Any comments please...thank you so kindly...
>
> Jay :-)
poster:cache-monkey
thread:489870
URL: http://www.dr-bob.org/babble/20050423/msgs/490104.html