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Re: What is the status of this drug ?? » zeugma

Posted by Ritch on April 19, 2005, at 9:54:29

In reply to Re: What is the status of this drug ?? » scatterbrained, posted by zeugma on April 18, 2005, at 17:45:04

>...Anxiety, it seems, is being reconceptualized as part of bipolar disorder. For example, I have seen it asserted that Generalized Anxiety Disorder and BP II are co-extensive. What this will mean in practical terms is that meds such as Lyrica, which are GABAergic and anticonvulsant, will be increasingly used for anxiety disorders, due to suspicion that anxiety is a manifestation of a bipolar disorder. Drugs such as the azapirones, of which buspirone is the only representative in clinical use, will be shelved, and not used for any indication whatsoever...

Z, that's an interesting statement there. I clearly have bipolar disorder, and when I tried buspirone it did *lower* anxiety, but it "shifted" it into anger and worsened rage problems. I think it had to do with the metabolite's alpha2-antagonist activity (other a2-antagonists do the same thing to me). I was hoping that gepirone would lack this activity and actually *help* the anxiety associated with my bipolar disorder. So, in my case I think it is a pity it isn't available, because I thought it held promise as a non-benzo anxiolytic that is also NOT a monoamine reuptake inhibitor that could treat my anxiety *without* worsening my bipolar disorder.--- Mitch


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