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NRIs w/o antichol fx? desipramine high dose vs low

Posted by iforgotmypassword on April 12, 2005, at 11:34:27

i take desipramine 300mg a day

-*good* for wakefulness, and does counter overeating (though *not always* reliable for this function) so 4 me it has been quite good for reversing vegetative symptoms of atypical depression, but im hoping it does not poop out like wellbutrin years ago.
-used to help me cry when i needed to, though is seldom reliable for this anymore. could it have been the lower dose?
(all of these helpful properties though i noticed early on and at low doses, BTW)

-causes dry mouth off and on, anticholinergic effects kinda wierd me out, i worry if its disrupting my thinking which is already very cloudy and unfocused. (earlier on and at lower doses, i had a urinary retention side effect as well)

what im wondering, if anyone can help me out, is:

1. are there any other NRIs, or norepinephrine active drugs that exist? are any of them specifically non-anticholinergic, non-sedative? i know there are other tricyclics... but know very little other details.

2. i noticed that desipramine helped me very early on and at a low dose. specific mood improving properties (if they exist) have been sketchier and any such help has been very hard to trace reliably to the drug itself since i can be so all over the place. is there any point in my taking such a high dose as 300mg when i think i can hardly tell a difference from 50-100mg like a year ago. its ironic that once my blood was tested at the 200mg dose, results came back saying i wasnt even in the therapeutic range... but i dont know what is really for sure about desipramine since i read a logically seeming article some while ago saying that high desipramine doses are not even needed though doctors still seem to prescribe them (has anyone else read this and can provide a link?)

THANX!!


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