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alpha2-agonists and parasympathomimetica

Posted by sdb on April 10, 2005, at 12:39:49

Does somebody have experience with alpha2-agonists like (clonodine...) to combat central over-noradrenaline transmission?

And is there somebody with parasympathomimetica experience?

I have found an interesting article for biochemical reasons of social phobia:

It is written

"While normal beta-adrenergic receptor number was observed in lymphocytes, a blunted response of growth hormone to clonidine, an a2-adrenergic agonist, was reported. This suggests reduced post-synaptic a2-adrenergic receptor functioning related to norepinephrine overactivity in social phobia. "

But in this article are more possible explanations, so there is obviously no ultimative trigger for social phobia (I personally suppose that individuals could have genetically and biochemically more responsiveness for sp, but i dont think there is a soul trigger organically).

Link

Pmid: 15538306

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15538306


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